The Journal of the Polish Biochemical Society
and of the Committee of Biochemistry and Biophysics
Polish Academy of Sciences

Acta Biochimica Polonica
Vol. 63 No. 4/2016

Acta Biochimica Polonica
Supplement 2, 2016
BIO 2016 Congress

Acta Biochimica Polonica
Supplement 1, 2016
X Parnas Conference

Selected Review from the Current Issue:

The role of the 5' terminal region of p53 mRNA in the p53 gene expression

Agata Swiatkowska

The p53 tumour suppressor protein is one of the major factors responsible for cell cycle regulation and protection against cancer development. This is why it is often referred to as "the guardian of the genome". On the other hand, mutations in the p53 gene are connected with more than 50% of tumours of various types. The thirty-six years of extensive research on the p53 gene and its protein products have shown how sophisticated the p53-based cell system control is. An additional level of complexity of the p53 research is connected with at least twelve p53 isoforms which have been identified in the cell. Importantly, disturbance of the p53 isoforms' expression seems to play a key role in tumorigenesis, cell differentiation and cell response to pathogenic bacteria, and RNA and DNA viruses. Expression of various p53 isoforms results from the usage of different transcription promoters, alternative splicing events and translation initiation from alternative AUG codons. The importance of the 5'-terminal regions of different p53 mRNA transcripts in the multi-level regulation of the p53 gene has recently been documented. In this review we focus on the structural features of these regions and their specific role in the p53 translation initiation process.

Acta Biochimica Polonica, 63(4), 645-651, Review, DOI: 10.18388/abp.2016_1342

Acta Biochimica Polonica is indexed in: Current Contents, Biochem. and Biophys. Citation Index, BIOSIS, Chemical Abstracts, Excerpta Medica, Medline, Index Copernicus, CBR

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