The Journal of the Polish Biochemical Society
and of the Committee of Biochemistry and Biophysics
Polish Academy of Sciences

Acta Biochimica Polonica
Vol. 63 No. 1/2016

Acta Biochimica Polonica
Supplement 1, 2015
Frontiers in Cancer Prevention

Acta Biochimica Polonica
Supplement 2, 2015
Weigl Conference on Microbiology

Selected Review from the Current Issue:

The factor VIII protein and its function

Anna Mazurkiewicz-Pisarek, Grażyna Płucienniczak, Tomasz Ciach and Andrzej Płucienniczak

Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ions. The role of factor VIII is to increase the catalytic efficiency of factor IXa in the activation of factor X. Variants of these factors lead frequently also to severe bleeding disorders.

Acta Biochimica Polonica, 63(1), 11-16, Review, DOI: 10.18388/abp.2015_1056

Acta Biochimica Polonica is indexed in: Current Contents, Biochem. and Biophys. Citation Index, BIOSIS, Chemical Abstracts, Excerpta Medica, Medline, Index Copernicus, CBR

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