The Journal of the Polish Biochemical Society
and of the Committee of Biochemistry and Biophysics
Polish Academy of Sciences

Acta Biochimica Polonica
Vol. 62 No. 2/2015

Acta Biochimica Polonica
Supplement 1, 2015
Frontiers in Cancer Prevention

Acta Biochimica Polonica
Supplement 2, 2015
Weigl Conference on Microbiology

Selected Review from the Current Issue:

The importance of liver lesions and changes to biochemical and coagulation factors in the pathogenesis of RHD

Alicja Trzeciak-Ryczek, Beata Tokarz-Deptuła and Wiesław Deptuła

RHDV (rabbit haemorrhagic disease virus) is an etiologic factor of RHD (rabbit haemorrhagic disease), which is highly morbid and mortal viral infection of an adult European rabbit. Although three decades have passed since the first outbreak of rabbit haemorrhagic disease, the pathogenesis of RHD has still not been fully elucidated. It is known that RHDV replicates in the liver within the first hours following infection, causing necrotic and apoptotic cell death of hepatocytes. Anatomopathological changes are also observed in other organs of infected rabbits, i.e. lungs, spleen, kidneys, heart, as well as central nerve system. These changes leading to animals death are predominantly caused by systemic hemorrhagic diathesis with disseminated intravascular coagulation (DIC), appearing most likely as a consequence of liver cell loss through RHDV-induced apoptosis. In this paper, we presented previously described changes in biochemical and coagulation factors in RHDV infection.

Acta Biochimica Polonica, 62(1), 169-171, Minireview, DOI: 10.18388/abp.2014_943

Acta Biochimica Polonica is indexed in: Current Contents, Biochem. and Biophys. Citation Index, BIOSIS, Chemical Abstracts, Excerpta Medica, Medline, Index Copernicus, CBR

Copyright © by Pawel Pomorski and Polish Biochemical Society 2015