The factor VIII protein and its function
Anna Mazurkiewicz-Pisarek, Grażyna Płucienniczak, Tomasz Ciach and Andrzej Płucienniczak
Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ions. The role of factor VIII is to increase the catalytic efficiency of factor IXa in the activation of factor X. Variants of these factors lead frequently also to severe bleeding disorders.
Acta Biochimica Polonica, 63(1), 11-16, Review, DOI: 10.18388/abp.2015_1056
Acta Biochimica Polonica is indexed in: Current Contents, Biochem. and Biophys. Citation Index, BIOSIS, Chemical Abstracts, Excerpta Medica, Medline, Index Copernicus, CBR
Acta Biochimica Polonica is a member of the Committee on Publication Ethics (COPE)
Copyright © by Pawel Pomorski and Polish Biochemical Society 2015